Genotoxicity of indium tin oxide by Allium and Comet tests.
Identifieur interne : 000676 ( Main/Exploration ); précédent : 000675; suivant : 000677Genotoxicity of indium tin oxide by Allium and Comet tests.
Auteurs : RBID : pubmed:24337653Abstract
Genotoxic effects of indium tin oxide (ITO) were investigated on root cells of Allium cepa by employing both Allium and Comet assays. A. cepa roots were treated with the aqueous dispersions of ITO at 5 different concentrations (12.5, 25, 50, 75, and 100 ppm) for 4 h. Exposure of ITO significantly increased mitotic index, and total chromosomal aberrations by the Allium test. While chromosome laggards, stickiness, disturbed anaphase-telophase and anaphase bridges were observed in anaphase-telophase cells, c-metaphase and binuclear cells were observed in other cells. A significant increase in DNA damage was also observed at all concentrations of ITO by the Comet assay. These results indicate that ITO exhibits genotoxic activity in A. cepa root meristematic cells.
DOI: 10.1007/s10616-013-9673-0
PubMed: 24337653
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genotoxicity of indium tin oxide by Allium and Comet tests.</title><author><name sortKey="Ci Erci, Ibrahim Hakk" uniqKey="Ci Erci I">Ibrahim Hakkı Ciğerci</name><affiliation wicri:level="1"><nlm:affiliation>Biology Department, Faculty of Science and Literatures, Afyon Kocatepe University, 03200, Afyon, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Biology Department, Faculty of Science and Literatures, Afyon Kocatepe University, 03200, Afyon</wicri:regionArea></affiliation></author><author><name sortKey="Liman, Recep" uniqKey="Liman R">Recep Liman</name></author><author><name sortKey="Ozg L, Emre" uniqKey="Ozg L E">Emre Ozgül</name></author><author><name sortKey="Konuk, Muhsin" uniqKey="Konuk M">Muhsin Konuk</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1007/s10616-013-9673-0</idno><idno type="RBID">pubmed:24337653</idno><idno type="pmid">24337653</idno><idno type="wicri:Area/Main/Corpus">000252</idno><idno type="wicri:Area/Main/Curation">000252</idno><idno type="wicri:Area/Main/Exploration">000676</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genotoxic effects of indium tin oxide (ITO) were investigated on root cells of Allium cepa by employing both Allium and Comet assays. A. cepa roots were treated with the aqueous dispersions of ITO at 5 different concentrations (12.5, 25, 50, 75, and 100 ppm) for 4 h. Exposure of ITO significantly increased mitotic index, and total chromosomal aberrations by the Allium test. While chromosome laggards, stickiness, disturbed anaphase-telophase and anaphase bridges were observed in anaphase-telophase cells, c-metaphase and binuclear cells were observed in other cells. A significant increase in DNA damage was also observed at all concentrations of ITO by the Comet assay. These results indicate that ITO exhibits genotoxic activity in A. cepa root meristematic cells.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">24337653</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>16</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0920-9069</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2013</Year><Month>Dec</Month><Day>12</Day></PubDate></JournalIssue><Title>Cytotechnology</Title><ISOAbbreviation>Cytotechnology</ISOAbbreviation></Journal><ArticleTitle>Genotoxicity of indium tin oxide by Allium and Comet tests.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><Abstract><AbstractText NlmCategory="UNLABELLED">Genotoxic effects of indium tin oxide (ITO) were investigated on root cells of Allium cepa by employing both Allium and Comet assays. A. cepa roots were treated with the aqueous dispersions of ITO at 5 different concentrations (12.5, 25, 50, 75, and 100 ppm) for 4 h. Exposure of ITO significantly increased mitotic index, and total chromosomal aberrations by the Allium test. While chromosome laggards, stickiness, disturbed anaphase-telophase and anaphase bridges were observed in anaphase-telophase cells, c-metaphase and binuclear cells were observed in other cells. A significant increase in DNA damage was also observed at all concentrations of ITO by the Comet assay. These results indicate that ITO exhibits genotoxic activity in A. cepa root meristematic cells.</AbstractText></Abstract><AuthorList><Author><LastName>Ciğerci</LastName><ForeName>Ibrahim Hakkı</ForeName><Initials>IH</Initials><Affiliation>Biology Department, Faculty of Science and Literatures, Afyon Kocatepe University, 03200, Afyon, Turkey.</Affiliation></Author><Author><LastName>Liman</LastName><ForeName>Recep</ForeName><Initials>R</Initials></Author><Author><LastName>Ozgül</LastName><ForeName>Emre</ForeName><Initials>E</Initials></Author><Author><LastName>Konuk</LastName><ForeName>Muhsin</ForeName><Initials>M</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType>JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Cytotechnology</MedlineTA><NlmUniqueID>8807027</NlmUniqueID><ISSNLinking>0920-9069</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>7</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>12</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s10616-013-9673-0</ArticleId><ArticleId IdType="pubmed">24337653</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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